TPDB

3D PDB MODEL

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TPDB ID TPDB92057

Peptide_Name

tMP-C

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 DRAMP Peptipedia CancerPPD 2.0 dbACP AFP-GFuse

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, DRAMP, Peptipedia, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

RKKRRQRRRLNLKALLAVAKKIL-NH2

FASTA

>TPDB92057|Antibacterial;Anticancer;Antifungal;Toxicity|length=23
RKKRRQRRRLNLKALLAVAKKIL-NH2

Formula C125H238N48O26

Absent Amino Acids DCEGHMFPSTWY

Common Amino Acids R

Mass 2829.57

PI 13.11

Basic Residues 11

Acidic Residues 0

Hydrophobic Residues 10

Net Charge +11

Boman Index 7.26

Hydrophobicity -0.887

Aliphatic Index 127.39

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

3

A

6

R

1

N

0

D

0

C

0

E

1

Q

0

G

0

H

1

I

5

L

5

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 3 R: 6 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 5 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

23

Formula

C125H238N48O26

Mass

2829.57

PI

13.11

Net Charge

+11

Boman Index

7.26

Hydrophobicity

-0.887

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial

Origin

Synthetic

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 2.79 µM

Detail Source Activity Anticancer

Activity Measurement 2.79 µM

Target

Cancer Type Lung Cancer

Cell Line H-157

Tissue Affected Lung

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2018

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 3.86 µM

Detail Source Activity Anticancer

Activity Measurement 3.86 µM

Target

Cancer Type Skin Cancer

Cell Line MDA-MB-435S

Tissue Affected Skin

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2018

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 3.86 µM

Detail Source Activity Anticancer

Activity Measurement 3.86 µM

Target

Cancer Type Prostate Cancer

Cell Line PC-3

Tissue Affected Prostate

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2018

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 3.36 µM

Detail Source Activity Anticancer

Activity Measurement 3.36 µM

Target

Cancer Type Brain tumor

Cell Line U-251-MG

Tissue Affected Brain

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2018

Evidence 5 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 3.70 µM

Detail Source Activity Anticancer

Activity Measurement 3.70 µM

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2018