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Peptide record

TPDB92056

NRC-13 Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB92056
NRC-13
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Biotinylated
Sequence
GWRTLLKKAEVKTVGKLALKHYL-NH2
Physicochemical Analysis
C125H210N34O29
NDCQIMFPS
LK
2653.25
10.76
7
1
11
+5
3.25
-0.178
118.70
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6990
263.45
3
Residue Composition
number
2
A
1
R
0
N
0
D
0
C
1
E
0
Q
2
G
1
H
0
I
5
L
5
K
0
M
0
F
0
P
0
S
2
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 1 I: 0 L: 5 K: 5 M: 0 F: 0 P: 0 S: 0 T: 2 W: 1 Y: 1 V: 2
Chemical Descriptors
23
C125H210N34O29
2653.25
10.76
+5
3.25
-0.178
Amidation
L
Linear
Biotinylated
Antimicrobial
Pleurocidin-family
Evidence Records 21 records
Evidence 1 Activity

Activity

~5% cytotoxic at 10 µM
Anticancer

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

10% cytotoxic at 25 µM
Anticancer

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 3 Activity

Activity

10-15% cytotoxic at 50 µM
Anticancer

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 4 Activity

Activity

~0% cytotoxic at 5 µM
Anticancer

Target

Breast Cancer
T-47D
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 5 Activity

Activity

~0% cytotoxic at 10 µM
Anticancer

Target

Breast Cancer
T-47D
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 6 Activity

Activity

10% cytotoxic at 25 µM
Anticancer

Target

Breast Cancer
T-47D
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 7 Activity

Activity

10-15% cytotoxic at 50 µM
Anticancer

Target

Breast Cancer
T-47D
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 8 Activity

Activity

10% cytotoxic at 5 µM
Anticancer

Target

Breast Cancer
SKBR-3
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 9 Activity

Activity

10% cytotoxic at 10 µM
Anticancer

Target

Breast Cancer
SKBR-3
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 10 Activity

Activity

10-15% cytotoxic at 25 µM
Anticancer

Target

Breast Cancer
SKBR-3
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 11 Activity

Activity

15-20% cytotoxic at 50 µM
Anticancer

Target

Breast Cancer
SKBR-3
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 12 Activity

Activity

~5% cytotoxic at 5 µM
Anticancer

Target

Breast Cancer
MDA-MB-468
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 13 Activity

Activity

~5% cytotoxic at 10 µM
Anticancer

Target

Breast Cancer
MDA-MB-468
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 14 Activity

Activity

5% cytotoxic at 25 µM
Anticancer

Target

Breast Cancer
MDA-MB-468
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 15 Activity

Activity

10-15% cytotoxic at 50 µM
Anticancer

Target

Breast Cancer
MDA-MB-468
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 16 Activity

Activity

~0% cytotoxic at 5 µM
Anticancer

Target

Breast Cancer
4T1
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 17 Activity

Activity

~0% cytotoxic at 10 µM
Anticancer

Target

Breast Cancer
4T1
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 18 Activity

Activity

5-10% cytotoxic at 25 µM
Anticancer

Target

Breast Cancer
4T1
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 19 Activity

Activity

20% cytotoxic at 50 µM
Anticancer

Target

Breast Cancer
4T1
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 20 Activity

Activity

0% cytotoxic at 50 µM
Anticancer

Target

Breast Cancer
MCF-7
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 21 Activity

Activity

~5% cytotoxic at 50 µM
Anticancer

Target

Breast Cancer
MCF-7-TX400
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011