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Peptide record

TPDB92055

17-DPS3 K5 Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB92055
17-DPS3 K5
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 Antifungipept CAFPdb PD_Hemolysis
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
ALWKKILKNAGKAALNKINQIVQ-NH2
Physicochemical Analysis
C118H204N34O29
RDCEHMFPSTY
K
2563.13
11.12
5
0
12
+5
2.31
-0.087
131.74
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
214.58
5
Residue Composition
number
4
A
0
R
3
N
0
D
0
C
0
E
2
Q
1
G
0
H
3
I
3
L
5
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 3 D: 0 C: 0 E: 0 Q: 2 G: 1 H: 0 I: 3 L: 3 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
23
C118H204N34O29
2563.13
11.12
+5
2.31
-0.087
Amidation
L
Linear
Free
Antimicrobial and Anticancer
Analogue of Dermaseptin-PS3
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
IC50 = 18.20 µM
Anticancer
18.20 µM

Target

Lung Cancer
H-157
Lung

Assay & Model

MTT assay
Not Available

Source & Reference

CancerPPD 2.0
CancerPPD2
2018

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 18.20 µM
Anticancer
18.20 µM

Target

Prostate Cancer
PC-3
Prostate

Assay & Model

MTT assay
Not Available

Source & Reference

CancerPPD 2.0
CancerPPD2
2018