TPDB

3D PDB MODEL

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TPDB ID TPDB92050

Peptide_Name

Dermaseptin-PH

Activity

Antibacterial Anticancer Antifungal

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP Peptipedia CancerPPD 2.0 dbACP Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 22-aa standard natural multi-activity (Antibacterial, Anticancer, and Antifungal) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

ALWKEVLKNAGKAALNEINNLV-NH2

FASTA

>TPDB92050|Antibacterial;Anticancer;Antifungal|length=22
ALWKEVLKNAGKAALNEINNLV-NH2

Formula C109H182N30O31

Absent Amino Acids RDCQHMFPSTY

Common Amino Acids ANL

Mass 2408.83

PI 9.76

Basic Residues 3

Acidic Residues 2

Hydrophobic Residues 12

Net Charge +1

Boman Index 3.76

Hydrophobicity 0.059

Aliphatic Index 133.18

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 228.33

Polar Residues 4

number

4

A

0

R

4

N

0

D

0

C

2

E

0

Q

1

G

0

H

1

I

4

L

3

K

0

M

0

F

0

P

0

S

0

T

1

W

0

Y

2

V

Amino Acid Distribution

A: 4 R: 0 N: 4 D: 0 C: 0 E: 2 Q: 0 G: 1 H: 0 I: 1 L: 4 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2

Length

22

Formula

C109H182N30O31

Mass

2408.83

PI

9.76

Net Charge

+1

Boman Index

3.76

Hydrophobicity

0.059

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial and Anticancer

Origin

Pithecopus (Phyllomedusa) hypochondrialis

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 0.69 µM

Detail Source Activity Anticancer

Activity Measurement 0.69 µM

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2017

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 2.01 µM

Detail Source Activity Anticancer

Activity Measurement 2.01 µM

Target

Cancer Type Lung Cancer

Cell Line H-157

Tissue Affected Lung

Assay & Model

Assay MTT assay

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2017

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 2.36 µM

Detail Source Activity Anticancer

Activity Measurement 2.36 µM

Target

Cancer Type Brain Tumor

Cell Line U251-MG

Tissue Affected Brain

Assay & Model

Assay MTT assay

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2017

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 9.94 µM

Detail Source Activity Anticancer

Activity Measurement 9.94 µM

Target

Cancer Type Breast Cancer

Cell Line MDA-MB-435S

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2017

Evidence 5 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 11.8 µM

Detail Source Activity Anticancer

Activity Measurement 11.8 µM

Target

Cancer Type Prostate Cancer

Cell Line PC-3

Tissue Affected Prostate

Assay & Model

Assay MTT assay

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2017