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Peptide record

TPDB92010

Transportan 10 Transportan 10 (TP10) transportan 10(TP10-NH2) TP-10 TP10 Antibacterial Anticancer Antifungal Antiparasitic Blood-Brain Barrier Cell-penetrating Peptides Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB92010
Transportan 10 Transportan 10 (TP10) transportan 10(TP10-NH2) TP-10 TP10
Antibacterial Anticancer Antifungal Antiparasitic Blood-Brain Barrier Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP Peptipedia Antifungipept CAFPdb dbAMP 3.0 i2APP B3Pred BBPpredict CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
AGYLLGKINLKALAALAKKIL-NH2
Physicochemical Analysis
C104H184N26O24
RDCEQHMFPSTWV
L
2182.76
10.64
4
0
14
+4
-1.37
0.933
172.38
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
68.26
2
Residue Composition
number
5
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
2
I
6
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 5 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 6 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
21
C104H184N26O24
2182.76
10.64
+4
-1.37
0.933
Amidation
L
Amphipathic Cationic Cationic and amphipathic
Linear
Free
N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)O N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 10 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, CHO and Jurkat cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Chimeric
Fluorophore [5(6)-carboxyfluorescein]
Cytoplasm
Clathrin mediated endocytosis
In vitro
CTTTSCCCCHHHHHTGGGGTC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Swiss 3T3 cells and bovine spermatozoa

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Protein derived
Fluorophore (TAMRA)
Mitochondria
Direct Translocation
In vitro
CTTTSCCCCHHHHHTGGGGTC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

HeLa cells

Source & Reference

CPPsite3.0
CPPsite3
US 2014/0140929 A1

Other

Natural residues Linear L Amphipathic
Chimeric
Nucleic acid (SCO)
Endocytosis
In vitro
CTTTSCCCCHHHHHTGGGGTC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

C. Albicans Sc5317

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Chimeric
Fluconazole (FLC) at N terminus via glutaric acid served as a linker
Increased fluorescence of the cells in comparison with the untreated growth controls (or cells treated with fluconazole)
Membrane damage
In vitro
CTTTSCCCCHHHHHTGGGGTC
Evidence 5 Activity

Activity

Cell-penetrating Peptides

Target

Mouse Brain Homogenates

Assay & Model

BALB/c male mice, weighing 30−36 g (8 months old)
BALB/c male mice, weighing 30−36 g (8 months old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Chimeric
dopamine (DA) via PEG4 (4,7,10,13-tetraoxapentadecanoic) linker.
TP10-DA conjugate in brain samples (group 3) was significantly higher (12.07 μg/g wet weight) in comparison to that in group 1 (0.9% NaCl) or group 2 (DA)
In vivo and ex vivo
CCGGGTSCC
Evidence 6 Activity

Activity

Cell-penetrating Peptides

Target

Hek293, Hepg2 And Llc-Pk1 Cells And C. Albicans And C. Glabrata

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
ciprofloxacin (CIP) or levofloxacin (LVX) and 5(6)-carboxyfluorescein
Cytoplasm
Both TP10(Cf)-NH2 and CIP-CH2CO-TP10(Cf)-NH2 were transported to and accumulated in Candida albicans cells, while CIP(Cf) did not enter these cells. On the other hand, none of the fluorescent probes were taken up by Candida glabrata.
In vitro
CCSSCGGGHHHHSCCC
Evidence 7 Activity

Activity

Cell-penetrating Peptides

Target

Rbl-2H3 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
TAMRA dye
Secretory Granules
TAMRA-TP10 show minimal colocalization (15.84 ± 5.4%, mean ± S.E.M.) with secretory granules
In vitro
CCCSSSTTCCCTTTTC
Evidence 8 Activity

Activity

Cell-penetrating Peptides

Assay & Model

ICR-CD-1 mice
ICR-CD-1 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic and amphipathic
Protein derived
Radio-Iodine labelled
Endocytosis and direct penetration
In vivo
CCCCCSSCTTSCSHHHHGGGTGGGSCCCC
Evidence 9 Activity

Activity

Cell-penetrating Peptides

Target

U87 Mg-Luc2

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Protein derived
Small interfering RNAs (siRNA)
In vitro
CCCSCSCCCCCC
Evidence 10 Activity

Activity

Cell-penetrating Peptides

Target

Giant Plasma Membrane Vesicles (Gpmv)Of Mb-231 And Rbl-2H3 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
Fluor 633 (AF633) dye
In vitro
CCSCSSCCCSCCCTHHHHHHHSCCC
Additional Detail Fields 1 fields
CTTTSCCCCHHHHHTGGGGTC CCGGGTSCC CCSSCGGGHHHHSCCC CCCSSSTTCCCTTTTC CCCCCSSCTTSCSHHHHGGGTGGGSCCCC CCCSCSCCCCCC CCSCSSCCCSCCCTHHHHHHHSCCC