Back to search

Peptide record

TPDB92009

TP10-2 Antibacterial Blood-Brain Barrier Cell-penetrating Peptides Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB92009
TP10-2
Antibacterial Blood-Brain Barrier Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia B3Pred BBPpredict CPPsite3.0 PerseuCPP
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Blood-Brain Barrier, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, Peptipedia, B3Pred, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
AGYLLGKINLKPLAALAKKIL-NH2
Physicochemical Analysis
C106H186N26O24
RDCEQHMFSTWV
L
2208.80
10.64
4
0
13
+4
-0.75
0.771
167.62
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
67.46
2
Residue Composition
number
4
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
2
I
6
L
4
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 6 K: 4 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
21
C106H186N26O24
2208.80
10.64
+4
-0.75
0.771
Amidation
L
Cationic and amphipathic
Linear
Free
N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Assay & Model

ICR-CD-1 mice
ICR-CD-1 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic and amphipathic
Synthetic
Radio-Iodine labelled
Direct translocation
In vivo
CCCCCCCSSCSTTTSCSHHHHHHHCSSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

E. coli ATCC 25922 cells and other Gram-negative and Gram-positive bacterias

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic and amphipathic
Chimeric
Cytoplasm
Time- and concentration-dependent internalization
Translocation via memrbane damage
In vitro
CCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCSSCSTTTSCSHHHHHHHCSSCC CCCCCCCC