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Peptide record

TPDB92008

TP10-8 Antibacterial Cell-penetrating Peptides Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB92008
TP10-8
Antibacterial Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CPPsite3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Cell-penetrating Peptides, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
AGYLLPKINLKPLAKLPKKIL-NH2
Physicochemical Analysis
C114H199N27O24
RDCEQHMFSTWV
L
2332.00
10.77
5
0
11
+5
1.47
0.281
158.10
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
63.89
2
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
6
L
5
K
0
M
0
F
3
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 6 K: 5 M: 0 F: 0 P: 3 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
21
C114H199N27O24
2332.00
10.77
+5
1.47
0.281
Amidation
L
Cationic and amphipathic
Linear
Free
N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

E. coli ATCC 25922 cells and other Gram-negative and Gram-positive bacterias

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic and amphipathic
Chimeric
Cytoplasm
Time- and concentration-dependent internalization
Translocation via memrbane damage
In vitro
CTTTSCCCCHHHHHTGGGGTC
Additional Detail Fields 1 fields
CTTTSCCCCHHHHHTGGGGTC