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Peptide record

TPDB92005

PEP-1 Antibacterial Anticancer Cell-penetrating Peptides Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB92005
PEP-1
Antibacterial Anticancer Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
N-terminal: Conjugation with 6 His-Tag
Sequence
KETWWETWWTEWSQPKKKRKV
Physicochemical Analysis
C136H195N35O33
ANDCGHILMFY
KW
2848.26
10.38
6
3
6
+3
4.22
-2.038
13.81
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
27500
965.50
5
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
3
E
1
Q
0
G
0
H
0
I
0
L
5
K
0
M
0
F
1
P
1
S
3
T
5
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 3 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 5 M: 0 F: 0 P: 1 S: 1 T: 3 W: 5 Y: 0 V: 1
Chemical Descriptors
21
C136H195N35O33
2848.26
10.38
+3
4.22
-2.038
Free
L
Linear
Conjugation with 6 His-Tag
N[C@@H](CCCCN)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H]([C@H](C)O)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(C)C)C1OO1
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Bv2 And SH-SY5Y Cell Lines

Assay & Model

Eight-week-old, male C57BL/6 mice
Eight-week-old, male C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Paraoxonase 1 (PON1) protein
Cytoplasm
Dose and time-dependent internalization in both cells
In vitro and in vivo
CCSSCCCCCCCCCCCSSCCCC
Additional Detail Fields 1 fields
CCSSCCCCCCCCCCCSSCCCC