Back to search

Peptide record

TPDB91997

Pep-1 Antibacterial Anticancer Cell-penetrating Peptides Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB91997
Pep-1
Antibacterial Anticancer Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
C-terminal: Cysteamidation Chemical: Nanoparticles N-terminal: Acetylation
Sequence
Ac-KETWWETWWTEWSQPKKKRKV
Physicochemical Analysis
C136H195N35O33
ANDCGHILMFY
KW
2848.26
10.38
6
3
6
+3
4.22
-2.038
13.81
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
27500
965.50
5
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
3
E
1
Q
0
G
0
H
0
I
0
L
5
K
0
M
0
F
1
P
1
S
3
T
5
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 3 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 5 M: 0 F: 0 P: 1 S: 1 T: 3 W: 5 Y: 0 V: 1
Chemical Descriptors
21
C136H195N35O33
2848.26
10.38
+3
4.22
-2.038
Cysteamidation
Nanoparticles
L
Amphipathic
Linear
Acetylation
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293T Cell Line

Assay & Model

6- to 8-week-old C57BL/6 female mice
6- to 8-week-old C57BL/6 female mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
HPV16 E7 protein
E7 delivery was detectable as in HEK-293T cells transfected with E7/Pep-1 nanoparticles as dominant band while the band doesnot appear in untransfected cells and transfected with E7 protein alone indicating that Pep-1 could transfer E7 protein into the cells.
In vitro and in vivo
CCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCC