TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB91990

Peptide_Name

CA-ME

Activity

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab HemoPI Hemolytic2 PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

KWKLFKKIGIGAVLKVLTTG-NH2

FASTA

>TPDB91990|Antibacterial;Anticancer;Antifungal;Antiparasitic;Hemolysis;Toxicity|length=20
KWKLFKKIGIGAVLKVLTTG-NH2

Formula C107H182N26O23

Absent Amino Acids RNDCEQHMPSY

Common Amino Acids K

Mass 2200.78

PI 11.12

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 10

Net Charge +5

Boman Index -0.05

Hydrophobicity 0.520

Aliphatic Index 131.50

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 249.91

Polar Residues 2

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

3

G

0

H

2

I

3

L

5

K

0

M

1

F

0

P

0

S

2

T

1

W

0

Y

2

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 2 L: 3 K: 5 M: 0 F: 1 P: 0 S: 0 T: 2 W: 1 Y: 0 V: 2

Length

20

Formula

C107H182N26O23

Mass

2200.78

PI

11.12

Net Charge

+5

Boman Index

-0.05

Hydrophobicity

0.520

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antibacterial

Origin

Ceropin A-Magainin 2

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=32.2 µM

Detail Source Activity Anticancer

Activity Measurement 32.2 µM

Target

Cancer Type Lung Cancer

Cell Line NCI-H69

Tissue Affected Lung

Assay & Model

Assay MTT/MTS assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1997

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=28.6 µM

Detail Source Activity Anticancer

Activity Measurement 28.6 µM

Target

Cancer Type Lung Cancer

Cell Line NCI-H128

Tissue Affected Lung

Assay & Model

Assay MTT/MTS assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1997

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=28.6 µM

Detail Source Activity Anticancer

Activity Measurement 28.6 µM

Target

Cancer Type Lung Cancer

Cell Line NCI-H146

Tissue Affected Lung

Assay & Model

Assay MTT/MTS assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1997