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Peptide record

TPDB91984

Ctn[15−34] Antibacterial Anticancer Antifungal Antiparasitic Cell-penetrating Peptides Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB91984
Ctn[15−34]
Antibacterial Anticancer Antifungal Antiparasitic Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb DRAMP dbAMP dbAMP 3.0 CPPsite3.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with 5(6)-Carboxyfluorescein (CF)
Sequence
KKRLKKIFKKPMVIGVTIPF-NH2
Physicochemical Analysis
C115H199N29O22S1
ANDCEQHSWY
K
2372.09
11.90
7
0
9
+7
3.96
0.050
107.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
3
I
1
L
6
K
1
M
2
F
2
P
0
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 1 K: 6 M: 1 F: 2 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
20
C115H199N29O22S1
2372.09
11.90
+7
3.96
0.050
Amidation
L
Cationic
Linear
Conjugated with 5(6)-Carboxyfluorescein (CF)
N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U937 And PBMCs

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
CF dye
Nucleus And Cell Membrane
CF-Ctn[15−34], variations in peptide uptake and cell morphology were only observed at the highest concentration. while at (25 μM), only few cells appeared to internalize.
Direct translocation and endocytosis (clathrin-mediated endocytosis)
In vitro
CCCGGGTGGGGGTGGGSGGGTTTSCCCCCCSCCC
Additional Detail Fields 1 fields
CCCGGGTGGGGGTGGGSGGGTTTSCCCCCCSCCC