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Peptide record

TPDB91973

cT1 Antibacterial Anticancer Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB91973
cT1
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 pep-lab Peptipedia CancerPPD 2.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Cyclized N-terminal: Cyclized
Sequence
KWCFRVCYRGICYRRCRG
Physicochemical Analysis
C101H157N35O21S4
ANDEQHLMPST
R
2325.82
10.10
6
0
6
+6
-1.00
-0.511
37.78
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
8730
375.35
6
Residue Composition
number
0
A
5
R
0
N
0
D
4
C
0
E
0
Q
2
G
0
H
1
I
0
L
1
K
0
M
1
F
0
P
0
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
18
C101H157N35O21S4
2325.82
10.10
+6
-1.00
-0.511
Cyclized
L
Cyclic
Cyclized
Host Defense Peptide
Synthetic
Evidence Records 7 records
Evidence 1 Activity

Activity

CC50
CC50 = 1.3 ± 0.1 µM
Anticancer
1.3

Target

Skin Cancer
MM96L
Skin

Assay & Model

Resazurin dye assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

CC50
CC50 = 1.4 ± 0.1 µM
Anticancer
1.4

Target

Skin Cancer
HT-144
Skin

Assay & Model

Resazurin dye assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
Evidence 3 Activity

Activity

CC50
CC50 = 2.7 ± 0.1 µM
Anticancer
2.7

Target

Skin Cancer
WM164
Skin

Assay & Model

Resazurin dye assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
Evidence 4 Activity

Activity

CC50
CC50 = 2.7 ± 0.3 µM
Anticancer
2.7

Target

Skin Cancer
MDA-MB-435S
Skin

Assay & Model

Resazurin dye assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
Evidence 5 Activity

Activity

CC50
CC50 = 2.0 ± 0.1 µM
Anticancer
2.0

Target

Leukemia Cancer
K-562
Blood

Assay & Model

Resazurin dye assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
Evidence 6 Activity

Activity

CC50
CC50 = 6.4 ± 0.6 µM
Anticancer
6.4

Target

Breast Cancer
MCF-7
Breast

Assay & Model

Resazurin dye assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
Evidence 7 Activity

Activity

CC50
CC50 = 6.7 ± 0.6 µM
Anticancer
6.7

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

Resazurin dye assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019