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Peptide record

TPDB91971

Protegrin 1 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB91971
Protegrin 1
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP pep-lab Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept CAFPdb i2APP AI4AVP dbAMP 3.0 CPPsite3.0 MLCPP 2.0 PerseuCPP APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
RGGRLCYCRRRFCVCVGR-NH2
Physicochemical Analysis
C88H150N36O20S4
ANDEQHIKMPSTW
R
2160.63
10.92
6
0
5
+6
1.44
-0.250
53.89
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1740
80.53
5
Residue Composition
number
0
A
6
R
0
N
0
D
4
C
0
E
0
Q
3
G
0
H
0
I
1
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
18
C88H150N36O20S4
2160.63
10.92
+6
1.44
-0.250
Amidation
L
Linear
Free
Antimicrobial
Alpha helical peptide without cysteines
Evidence Records 2 records
Evidence 1 Activity

Activity

61% Cytotoxicity at 0.5 µg/ml
Anticancer

Target

Lymphoma Cancer
U-937
Blood

Assay & Model

MTT/MTS assay
6-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
1993

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.
Evidence 2 Activity

Activity

IC50
IC50 =30-40 µg/ml
Anticancer
30-40 µg/mL

Target

Lymphoma Cancer
U-942
Blood

Assay & Model

MTT/MTS assay
Not Available

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011