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Peptide record

TPDB91960

pVec Antibacterial Antifungal Antiparasitic Blood-Brain Barrier Cell-penetrating Peptides Toxicity Tumor-homing Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB91960
pVec
Antibacterial Antifungal Antiparasitic Blood-Brain Barrier Cell-penetrating Peptides Toxicity Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP i2APP B3Pred BBPpredict CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP TumorHoPe2.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Chemical: DiI-labelled liposomes modified with transferrin (Tf)
Sequence
LLIILRRRIRKQAHAHSK
Physicochemical Analysis
C98H177N37O21
NDCEGMFPTWYV
R
2209.72
12.88
8
0
8
+6
4.90
-0.444
141.11
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
2
A
4
R
0
N
0
D
0
C
0
E
1
Q
0
G
2
H
3
I
3
L
2
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 2 I: 3 L: 3 K: 2 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C98H177N37O21
2209.72
12.88
+6
4.90
-0.444
Free
DiI-labelled liposomes modified with transferrin (Tf)
L
Amphipathic
Linear
Free
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

bEnd.3, Glial And Primary Neuronal Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
plasmid DNA
The uptake of all liposomal formulations increased on average from 33% to 71% in bEnd.3 cells, 35% to 66% in glial cells and In primary neuronal cells from 33% to 65%, were observed after 1 hour and 4 hours of incubation. TAT-Tf-liposomes containing chitosan–pGFP complexes induced significantly (p<0.05) higher GFP levels compared to pVec-Tf-lip and QL-Tf-lip (7.2% vs 4.2% and 2.8% GFP-expressing cells, respectively).
Clathrin- and Caveolae-dependent endocytosis and macropinocytosis
In vitro
CCCCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCCCC