TPDB

3D PDB MODEL

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TPDB ID TPDB91952

Peptide_Name

[S9]-P18

Activity

Antibacterial Anticancer Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP dbAMP 3.0 iACP-DRLF pep-lab HemoPI Hemolytic2 PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

KWKLFKKISKFLHLAKKF-NH2

FASTA

>TPDB91952|Antibacterial;Anticancer;Hemolysis;Toxicity|length=18
KWKLFKKISKFLHLAKKF-NH2

Formula C116H184N28O20

Absent Amino Acids RNDCEQGMPTYV

Common Amino Acids K

Mass 2290.91

PI 11.29

Basic Residues 8

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +7

Boman Index 0.62

Hydrophobicity -0.339

Aliphatic Index 92.22

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 240.08

Polar Residues 1

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

1

H

1

I

3

L

7

K

0

M

3

F

0

P

1

S

0

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 3 K: 7 M: 0 F: 3 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0

Length

18

Formula

C116H184N28O20

Mass

2290.91

PI

11.29

Net Charge

+7

Boman Index

0.62

Hydrophobicity

-0.339

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antibacterial

Origin

Ceropin A

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=4 µM

Detail Source Activity Anticancer

Activity Measurement 4 µM

Target

Cancer Type Breast Cancer

Cell Line MDA-MB-361

Tissue Affected Breast

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2001

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=7 µM

Detail Source Activity Anticancer

Activity Measurement 7 µM

Target

Cancer Type Blood Cancer

Cell Line Jurkat

Tissue Affected Blood

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2001

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=3 µM

Detail Source Activity Anticancer

Activity Measurement 3 µM

Target

Cancer Type Leukemia Cancer

Cell Line K-562

Tissue Affected Blood

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2001