TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB91948

Peptide_Name

AP1-Z1

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 iACP-DRLF Antifungipept CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation N-terminal: Amidation

Sequence

FLFSLIPHAISGLISAFK-NH2

FASTA

>TPDB91948|Antibacterial;Anticancer;Antifungal;Toxicity|length=18
FLFSLIPHAISGLISAFK-NH2

Formula C97H149N21O22

Absent Amino Acids RNDCEQMTWYV

Common Amino Acids ILFS

Mass 1961.38

PI 10.10

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 11

Net Charge +1

Boman Index -3.54

Hydrophobicity 1.411

Aliphatic Index 141.11

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

2

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

1

H

3

I

3

L

1

K

0

M

3

F

1

P

3

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 3 L: 3 K: 1 M: 0 F: 3 P: 1 S: 3 T: 0 W: 0 Y: 0 V: 0

Length

18

Formula

C97H149N21O22

Mass

1961.38

PI

10.10

Net Charge

+1

Boman Index

-3.54

Hydrophobicity

1.411

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Amidation

Nature

Antimicrobial

Origin

AcrAP1 from the venom of the Arabian scorpion

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 7.222 µM

Detail Source Activity Anticancer

Activity Measurement 7.222 µM

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2019

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 9.478 µM

Detail Source Activity Anticancer

Activity Measurement 9.478 µM

Target

Cancer Type Skin Cancer

Cell Line A-375

Tissue Affected Skin

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2019

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 10.21 µM

Detail Source Activity Anticancer

Activity Measurement 10.21 µM

Target

Cancer Type Brain Tumor

Cell Line U-87

Tissue Affected Brain

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2019