TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB91938

Peptide_Name

[Y7W, K8R, Y14W]cGm

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 dbACP dbAMP 3.0 AFP-GFuse CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Modification

C-terminal: Cyclized N-terminal: Cyclized

Sequence

GCRRLCWRQRCVTWCRGR

FASTA

>TPDB91938|Antibacterial;Anticancer;Antifungal;Toxicity|length=18
GCRRLCWRQRCVTWCRGR

Formula C94H155N39O21S4

Absent Amino Acids ANDEHIKMFPSY

Common Amino Acids R

Mass 2295.75

PI 11.71

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +6

Boman Index 0.45

Hydrophobicity -0.878

Aliphatic Index 37.78

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 11250

Absorbance 280nm 490.04

Polar Residues 6

number

0

A

6

R

0

N

0

D

4

C

0

E

1

Q

2

G

0

H

0

I

1

L

0

K

0

M

0

F

0

P

0

S

1

T

2

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 6 N: 0 D: 0 C: 4 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 2 Y: 0 V: 1

Length

18

Formula

C94H155N39O21S4

Mass

2295.75

PI

11.71

Net Charge

+6

Boman Index

0.45

Hydrophobicity

-0.878

C_terminal_Modification

Cyclized

Chirality

L

Linear_or_Cyclic

Cyclic

N_terminal_Modification

Cyclized

Nature

Antimicrobial

Origin

Synthetic Analogue of Gomesin

Evidence 1 Activity

Activity

Activity Endpoint CC50

Activity Raw

CC50 = 31.6 ± 1.3 µM

Detail Source Activity Anticancer

Activity Measurement 31.6

Target

Cancer Type Gastric Cancer

Cell Line CRL-1739

Tissue Affected Stomach

Assay & Model

Assay Resazurin dye assay

Testing Time 24-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2017

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.

Evidence 2 Activity

Activity

Activity Endpoint CC50

Activity Raw

CC50 = 5.4 ± 0.3 µM

Detail Source Activity Anticancer

Activity Measurement 5.4

Target

Cancer Type Skin Cancer

Cell Line MM96L

Tissue Affected Skin

Assay & Model

Assay Resazurin dye assay

Testing Time 24-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2017

Evidence 3 Activity

Activity

Activity Endpoint CC50

Activity Raw

CC50 = 41.0 ± 4.2 µM

Detail Source Activity Anticancer

Activity Measurement 41.0

Target

Cancer Type Cervical Cancer

Cell Line HeLa

Tissue Affected Cervix

Assay & Model

Assay Resazurin dye assay

Testing Time 24-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2017

Evidence 4 Activity

Activity

Activity Endpoint CC50

Activity Raw

CC50 = 15.1 ± 1.4 µM

Detail Source Activity Anticancer

Activity Measurement 15.1

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay Resazurin dye assay

Testing Time 24-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2017

Evidence 5 Activity

Activity

Activity Endpoint CC50

Activity Raw

CC50 = 3.9 ± 0.1 µM

Detail Source Activity Anticancer

Activity Measurement 3.9

Target

Cancer Type Leukemia Cancer

Cell Line K-562

Tissue Affected Blood

Assay & Model

Assay Resazurin dye assay

Testing Time 24-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2017