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Peptide record

TPDB91936

[R4A, R18A]cGm Antibacterial Anticancer Antifungal Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB91936
[R4A, R18A]cGm
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 dbACP dbAMP 3.0 Antifungipept CAFPdb
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
C-terminal: Cyclized N-terminal: Cyclized
Sequence
GCRALCYKQRCVTYCRGA
Physicochemical Analysis
C84H139N29O23S4
NDEHIMFPSW
C
2051.45
9.17
4
0
6
+4
0.49
-0.189
48.89
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3230
157.45
8
Residue Composition
number
2
A
3
R
0
N
0
D
4
C
0
E
1
Q
2
G
0
H
0
I
1
L
1
K
0
M
0
F
0
P
0
S
1
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 0 C: 4 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 2 V: 1
Chemical Descriptors
18
C84H139N29O23S4
2051.45
9.17
+4
0.49
-0.189
Cyclized
L
Cyclic
Cyclized
Antimicrobial
Synthetic Analogue of Gomesin
Evidence Records 6 records
Evidence 1 Activity

Activity

CC50
CC50 > 64 µM
Anticancer
64 µM

Target

Gastric Cancer
CRL-1739
Stomach

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2017

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.
Evidence 2 Activity

Activity

CC50
CC50 = 10.3 ± 1.1 µM
Anticancer
10.3

Target

Skin Cancer
MM96L
Skin

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2017
Evidence 3 Activity

Activity

CC50
CC50 > 64 µM
Anticancer
64 µM

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2017
Evidence 4 Activity

Activity

CC50
CC50 = 48.4 ± 0.7 µM
Anticancer
48.4

Target

Breast Cancer
MCF-7
Breast

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2017
Evidence 5 Activity

Activity

CC50
CC50 = 11.5 ± 0.6 µM
Anticancer
11.5

Target

Leukemia Cancer
K-562
Blood

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2017
Evidence 6 Activity

Activity

CC50
CC50 = 34.1 ± 3.9 µM
Anticancer
34.1

Target

Leukemia Cancer
HL-60
Blood

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP
CancerPPD2
2017