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Peptide record

TPDB91934

ApoEdp Antibacterial Blood-Brain Barrier Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB91934
ApoEdp
Antibacterial Blood-Brain Barrier Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia B3Pred BBPpredict CPPsite3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Blood-Brain Barrier, and Cell-penetrating Peptides) peptide sequence curated from AntiBP3, Peptipedia, B3Pred, and other sources, with an available 3D structural model.
N-terminal: Conjugated with CF Via GGG Linker
Sequence
LRKLRKRLLLRKLRKRLL
Physicochemical Analysis
C108H210N40O19
ANDCEQGHIMFPSTWYV
L
2373.11
13.10
10
0
8
+10
4.34
-0.678
173.33
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
8
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 8 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C108H210N40O19
2373.11
13.10
+10
4.34
-0.678
Free
L
Linear
Conjugated with CF Via GGG Linker
N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

hCMEC/D3 Cell

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
CF dye
Showed significantly higher permeability than FD-4 and all other BBB penetrating peptides.
In vitro
CCCCCSBSSSBSCCSSSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

hCMEC/D3 Cell

Assay & Model

Five-week-old male ddY mice
Five-week-old male ddY mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
PEGylated liposomes
In vitro and in vivo
CEETTEECSSCC
Additional Detail Fields 1 fields
CCCCCSBSSSBSCCSSSCC CEETTEECSSCC