TPDB

3D PDB MODEL

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TPDB ID TPDB91933

Peptide_Name

ASA-APOEII

Activity

Antibacterial Blood-Brain Barrier Cell-penetrating Peptides

Activity_category_statistics

Anti-infective peptides Delivery and barrier-penetrating peptides

Database_Source

AntiBP3 Peptipedia B3Pred BBPpredict CPPsite3.0

Sequence_Type

standard

Has_Modification No

Description A 18-aa standard natural multi-activity (Antibacterial, Blood-Brain Barrier, and Cell-penetrating Peptides) peptide sequence curated from AntiBP3, Peptipedia, B3Pred, and other sources, with an available 3D structural model.

Modification

N-terminal: Conjugated with ASA drug

Sequence

LRKLRKRLLLRKLRKRLL

FASTA

>TPDB91933|Antibacterial;Blood-Brain Barrier;Cell-penetrating Peptides|length=18
LRKLRKRLLLRKLRKRLL

Formula C108H210N40O19

Absent Amino Acids ANDCEQGHIMFPSTWYV

Common Amino Acids L

Mass 2373.11

PI 13.10

Basic Residues 10

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +10

Boman Index 4.34

Hydrophobicity -0.678

Aliphatic Index 173.33

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

6

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

8

L

4

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 8 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

18

Formula

C108H210N40O19

Mass

2373.11

PI

13.10

Net Charge

+10

Boman Index

4.34

Hydrophobicity

-0.678

Conformation

Linear

N_terminal_Modification

Conjugated with ASA drug

Peptide_Length

Similarity

Peptide_Sequence_3Letter

LeuArgLysLeuArgLysArgLeuLeuLeuArgLysLeuArgLysArgLeuLeu

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Target

Cell Line CHO cell line

Assay & Model

In Vitro Concentration 2.5 microgram/ ml

In Vitro Method cellular uptake assay

In Vitro Result 32 % cellular uptake

Animal Model Origin/Source

Physical Condition Lysosomal disorder

Source & Reference

Database Source NA

Source B3Pdb

Other

Transport Type Transendocytosis

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Target

Cell Line bEND cell line

Assay & Model

In Vitro Concentration 2.5 microgram/ ml

In Vitro Method cellular uptake assay

In Vitro Result 19.3 % cellular uptake

Animal Model Origin/Source

Physical Condition Lysosomal disorder

Source & Reference

Database Source NA

Source B3Pdb

Other

Transport Type Transendocytosis

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Target

Cell Line PBCECs cell line

Assay & Model

In Vitro Concentration 0.02% cells were added

In Vitro Method Basolateral screening assay

In Vitro Result 150% transfer

Animal Model Origin/Source

Physical Condition Lysosomal disorder

Source & Reference

Database Source NA

Source B3Pdb

Other

Transport Type Basolateral