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Peptide record

TPDB91925

AP1-Z5a Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB91925
AP1-Z5a
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia CancerPPD 2.0 Antifungipept CAFPdb PD_Hemolysis
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Amidation
Sequence
FLFKLIPKAIKGLIKAFK-NH2
Physicochemical Analysis
C106H175N23O19
RNDCEQHMSTWYV
K
2075.70
11.12
5
0
11
+5
-0.93
0.856
141.11
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
3
I
3
L
5
K
0
M
3
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 3 K: 5 M: 0 F: 3 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C106H175N23O19
2075.70
11.12
+5
-0.93
0.856
Amidation
L
Linear
Amidation
Antimicrobial
Mutant of APR-Z1
Evidence Records 3 records
Evidence 1 Activity

Activity

Graph Figure 2A
Anticancer

Target

Breast Cancer
MCF-7
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

Graph Figure 2B
Anticancer

Target

Skin Cancer
A-375
Skin

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
Evidence 3 Activity

Activity

Graph Figure 2C
Anticancer

Target

Brain Tumor
U-87
Brain

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019