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Peptide record

TPDB91924

polyphemusin I Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB91924
polyphemusin I
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb AI4AVP dbAMP 3.0 CPPsite3.0 APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
RRWCFRVCYRGFCYRKCR-NH2
Physicochemical Analysis
C108H164N38O21S4
ANDEQHILMPST
R
2458.97
10.57
7
0
6
+7
-1.02
-0.833
16.11
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
8730
355.03
6
Residue Composition
number
0
A
6
R
0
N
0
D
4
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
2
F
0
P
0
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
18
C108H164N38O21S4
2458.97
10.57
+7
-1.02
-0.833
Amidation
L
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Bmm Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Protein derived
Alexa Fluor 488-conjugated
Internalized into~100% BMMs at 1 μM
In vitro