TPDB

3D PDB MODEL

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TPDB ID TPDB91918

Peptide_Name

TsAP-1

Activity

Antibacterial Anticancer Antifungal Antiviral Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

FLSLIPSLVGGSISAFK-NH2

FASTA

>TPDB91918|Antibacterial;Anticancer;Antifungal;Antiviral;Toxicity|length=17
FLSLIPSLVGGSISAFK-NH2

Formula C83H134N18O22

Absent Amino Acids RNDCEQHMTWY

Common Amino Acids S

Mass 1736.08

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +1

Boman Index -2.68

Hydrophobicity 1.324

Aliphatic Index 137.65

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 4

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

2

G

0

H

2

I

3

L

1

K

0

M

2

F

1

P

4

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 3 K: 1 M: 0 F: 2 P: 1 S: 4 T: 0 W: 0 Y: 0 V: 1

Length

17

Formula

C83H134N18O22

Mass

1736.08

PI

10.10

Net Charge

+1

Boman Index

-2.68

Hydrophobicity

1.324

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial

Origin

Venom-derived cDNot Available library of the Brazilian yellow scorpion, Tityus serrulatus

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 =55.9 µM

Detail Source Activity Anticancer

Activity Measurement 55.9 µM

Target

Cancer Type Lung Cancer

Cell Line HI-57

Tissue Affected Lung

Assay & Model

Assay MTT/MTS assay

Testing Time 24-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2013

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 =52.5 µM

Detail Source Activity Anticancer

Activity Measurement 52.5 µM

Target

Cancer Type Lung Cancer

Cell Line H-838

Tissue Affected Lung

Assay & Model

Assay MTT/MTS assay

Testing Time 24-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2013