TPDB

3D PDB MODEL

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TPDB ID TPDB91917

Peptide_Name

CA-MA1

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab Antifungipept dbAMP 3.0 i2APP AI4AVP

Sequence_Type

standard

Has_Modification No

Description A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

KWKLFKKIKFLHSAKKF-NH2

FASTA

>TPDB91917|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Toxicity|length=17
KWKLFKKIKFLHSAKKF-NH2

Formula C110H173N27O19

Absent Amino Acids RNDCEQGMPTYV

Common Amino Acids K

Mass 2177.75

PI 11.29

Basic Residues 8

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +7

Boman Index 1.18

Hydrophobicity -0.582

Aliphatic Index 74.71

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 252.55

Polar Residues 1

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

1

H

1

I

2

L

7

K

0

M

3

F

0

P

1

S

0

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 2 K: 7 M: 0 F: 3 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0

Length

17

Formula

C110H173N27O19

Mass

2177.75

PI

11.29

Net Charge

+7

Boman Index

1.18

Hydrophobicity

-0.582

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antibacterial

Origin

Ceropin-Magainin hybrid peptides

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=85.3 µM

Detail Source Activity Anticancer

Activity Measurement 85.3 µM

Target

Cancer Type Leukemia Cancer

Cell Line K-562

Tissue Affected Blood

Assay & Model

Assay MTT/MTS assay

Testing Time 72-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2000

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=100 µM

Detail Source Activity Anticancer

Activity Measurement 100 µM

Target

Cancer Type Lung Cancer

Cell Line A-549

Tissue Affected Lung

Assay & Model

Assay MTT/MTS assay

Testing Time 72-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2000

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=65 µM

Detail Source Activity Anticancer

Activity Measurement 65 µM

Target

Cancer Type Blood Cancer

Cell Line Jurkat

Tissue Affected Blood

Assay & Model

Assay MTT/MTS assay

Testing Time 72-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2000

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=100 µM

Detail Source Activity Anticancer

Activity Measurement 100 µM

Target

Cancer Type Breast Cancer

Cell Line MDA-MB-361

Tissue Affected Breast

Assay & Model

Assay MTT/MTS assay

Testing Time 72-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2000