TPDB

3D PDB MODEL

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TPDB ID TPDB91915

Peptide_Name

Bombinin-H-BO1

Activity

Antibacterial Anticancer Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia CancerPPD 2.0 dbACP AFP-GFuse Antifungipept CAFPdb dbAMP APD_complete PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

IIGPVLGLVGKALGGLL-NH2

FASTA

>TPDB91915|Antibacterial;Anticancer;Antifungal;Hemolysis;Toxicity|length=17
IIGPVLGLVGKALGGLL-NH2

Formula C76H136N18O18

Absent Amino Acids RNDCEQHMFSTWY

Common Amino Acids GL

Mass 1590.03

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 10

Net Charge +1

Boman Index -1.96

Hydrophobicity 1.806

Aliphatic Index 200.59

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

5

G

0

H

2

I

5

L

1

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 5 H: 0 I: 2 L: 5 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 2

Length

17

Formula

C76H136N18O18

Mass

1590.03

PI

10.10

Net Charge

+1

Boman Index

-1.96

Hydrophobicity

1.806

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial

Origin

Bombina orientalis

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 3.61 µM

Detail Source Activity Anticancer

Activity Measurement 3.61 µM

Target

Cancer Type Liver Cancer

Cell Line SK-HEP-1

Tissue Affected Liver

Assay & Model

Assay MTT assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2018

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 8.08 µM

Detail Source Activity Anticancer

Activity Measurement 8.08 µM

Target

Cancer Type Liver Cancer

Cell Line HepG-2

Tissue Affected Liver

Assay & Model

Assay MTT assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2018

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 8.42 µM

Detail Source Activity Anticancer

Activity Measurement 8.42 µM

Target

Cancer Type Liver Cancer

Cell Line Huh-7

Tissue Affected Liver

Assay & Model

Assay MTT assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2018