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Peptide record

TPDB91903

TsAP-2 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB91903
TsAP-2
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb AVPpred-BWR dbAMP 3.0 APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
FLGMIPGLIGGLISAFK-NH2
Physicochemical Analysis
C84H136N18O19S1
RNDCEQHTWYV
G
1734.17
10.10
1
0
10
+1
-3.66
1.547
143.53
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
4
G
0
H
3
I
3
L
1
K
1
M
2
F
1
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 3 L: 3 K: 1 M: 1 F: 2 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
17
C84H136N18O19S1
1734.17
10.10
+1
-3.66
1.547
Amidation
L
Linear
Free
Antimicrobial
Venom-derived cDNot Available library of the Brazilian yellow scorpion, Tityus serrulatus
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
IC50 = 4.1 µM
Anticancer
4.1 µM

Target

Lung Cancer
HI-57
Lung

Assay & Model

MTT/MTS assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2013

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.
Evidence 2 Activity

Activity

IC50
IC50 = 11.0 µM
Anticancer
11.0 µM

Target

Lung Cancer
H-838
Lung

Assay & Model

MTT/MTS assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2013
Evidence 3 Activity

Activity

IC50
IC50 = 6.4 µM
Anticancer
6.4 µM

Target

Breast Cancer
MCF-7
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2013
Evidence 4 Activity

Activity

IC50
IC50 = 13.3 µM
Anticancer
13.3 µM

Target

Prostate Cancer
PC-3
Prostate

Assay & Model

MTT/MTS assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2013
Evidence 5 Activity

Activity

IC50
IC50 = 15.4 µM
Anticancer
15.4 µM

Target

Brain Tumor
U251-MG
Brain

Assay & Model

MTT/MTS assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2013