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Peptide record

TPDB91901

[I11A]tachyplesin I Antibacterial Antifungal Cell-penetrating Peptides Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB91901
[I11A]tachyplesin I
Antibacterial Antifungal Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb CPPsite3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Antifungal, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
KWCFRVCYRGACYRRCR-NH2
Physicochemical Analysis
C96H148N34O20S4
NDEQHILMPST
R
2226.69
10.10
6
0
6
+6
-0.87
-0.676
22.94
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
8730
392.06
6
Residue Composition
number
1
A
5
R
0
N
0
D
4
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
1
F
0
P
0
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 5 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
17
C96H148N34O20S4
2226.69
10.10
+6
-0.87
-0.676
Amidation
L
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Bmm Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Synthetic
Alexa Fluor 488-conjugated
Vesicles
The [I11A] and [I11S]tachyplesin I analogs internalized more efficiently into BMMs, with >tenfold lower concentrations required to internalise 50% of cells compared to tachyplesin I
In vitro