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Peptide record

TPDB91869

Penetratin (Pen) Antibacterial Anticancer Antifungal Antiviral Blood-Brain Barrier Cell-penetrating Peptides Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB91869
Penetratin (Pen)
Antibacterial Anticancer Antifungal Antiviral Blood-Brain Barrier Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF pep-lab Antifungipept CAFPdb AI4AVP B3Pred BBPpredict CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Chemical: Transferrin (Tf) modified liposomes
Sequence
RQIKIWFQNRRMKWKK
Physicochemical Analysis
C104H168N34O20S1
ADCEGHLPSTYV
K
2246.75
12.72
7
0
6
+7
2.29
-1.731
48.75
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
489.60
3
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
2
Q
0
G
0
H
2
I
0
L
4
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
16
C104H168N34O20S1
2246.75
12.72
+7
2.29
-1.731
Free
Transferrin (Tf) modified liposomes
L
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

bEnd.3, Primary Glial And Primary Neuronal Cells.

Assay & Model

C57BL/6 (male/female) mice
C57BL/6 (male/female) mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Chitosan-pApoE2
Tf-Pen-liposomes (20.8 ± 4.0 ng/μg of protein) significantly (p < 0.05) increased ApoE expression in the brain of mice compared to unmodified liposomes (14.4 ± 3.4 ng/μg of protein), naked plasmid ApoE2 (3.4 ± 1.8 ng/μg of protein) and endogenous ApoE levels (2.5 ± 2.0 ng/μg of protein).
In vitro and in vivo