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Peptide record

TPDB91842

pAntp Penetratin (pAntp) (43-58) Penetratin {pAntp-(43-58)} XV Antibacterial Anticancer Antifungal Antiviral Blood-Brain Barrier Cell-penetrating Peptides Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB91842
pAntp Penetratin (pAntp) (43-58) Penetratin {pAntp-(43-58)} XV
Antibacterial Anticancer Antifungal Antiviral Blood-Brain Barrier Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF pep-lab Antifungipept CAFPdb AI4AVP B3Pred BBPpredict CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugation with fluorescein
Sequence
RQIKIWFQNRRMKWKK-NH2
Physicochemical Analysis
C104H168N34O20S1
ADCEGHLPSTYV
K
2246.75
12.72
7
0
6
+7
2.29
-1.731
48.75
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
489.60
3
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
2
Q
0
G
0
H
2
I
0
L
4
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
16
C104H168N34O20S1
2246.75
12.72
+7
2.29
-1.731
Amidation
L
Amphipathic Cationic and amphipathic
Linear
Conjugation with fluorescein
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 12 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Aortic endothelial cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
Fluorophore (fluorescein)
Cytoplasm and nucleus
Non-endocytic mechanism
In vitro
CCCSSSTTCCCTTTTC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

PC-12 and V79 cells

Source & Reference

CPPsite3.0
CPPsite3
US 7153931

Other

Natural residues Linear L Amphipathic
Protein derived
Fluorophore (fluorescein)
Uneven distribution of peptide with accumulation in centrosmal area and in
Endocytic pathway
In vitro
CCCSSSTTCCCTTTTC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Protein derived
Fluorophore (fluorescein)
In vitro
CCCSSSTTCCCTTTTC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, CHO K1

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Protein derived
Fluorophore (fluorescein)
In vitro
CCCSSSTTCCCTTTTC
Evidence 5 Activity

Activity

Cell-penetrating Peptides

Target

MDCK cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Protein derived
Fluorophore (fluorescein)
Surface of the plasma membrane and intracellular vesicles
In vitro
CCCSSSTTCCCTTTTC
Evidence 6 Activity

Activity

Cell-penetrating Peptides

Target

Calu-3 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Protein derived
Fluorophore (fluorescein)
Punctuated cytoplasmic (vesicles) as well as extracellular staining
In vitro
CCCSSSTTCCCTTTTC
Evidence 7 Activity

Activity

Cell-penetrating Peptides

Target

TR146 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Protein derived
Fluorophore (fluorescein)
Punctuated cytoplasmic pattern (vesicles)
In vitro
CCCSSSTTCCCTTTTC
Evidence 8 Activity

Activity

Cell-penetrating Peptides

Target

Human SH-SY5Y, N2A and Human bowes melanoma cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Protein derived
Fluorophore (fluorescein)
In vitro
CCCSSSTTCCCTTTTC
Evidence 9 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Protein derived
Fluorophore (fluorescein)
Vesicles
In vitro
CCCSSSTTCCCTTTTC
Evidence 10 Activity

Activity

Cell-penetrating Peptides

Target

MC57

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Protein derived
Fluorophore (fluorescein)
Cytoplasm
In vitro
CCCSSSTTCCCTTTTC
Evidence 11 Activity

Activity

Cell-penetrating Peptides

Target

RBL-2H3 cells, CHO-K1

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic and amphipathic
Protein derived
Fluorophore (Fluorescein)
Vesicles
Non-endocytic mechanism
In vivo
CCCSSSTTCCCTTTTC
Evidence 12 Activity

Activity

Cell-penetrating Peptides

Target

Rat basophilic leukemia RBL-2H3 cells and CHO-K1

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic and amphipathic
Protein derived
Fluorophore (Fluorescein)
Lower uptake efficiency
Non-endocytic mechanism
In vitro
CCCSSSTTCCCTTTTC
Additional Detail Fields 1 fields
CCCSSSTTCCCTTTTC