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Peptide record

TPDB91826

retro Antibacterial Anticancer Antifungal Toxicity standard

16 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB91826

Peptide_Name

retro

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab Antifungipept CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

LGGIVSAVKKIVDFLG-NH2

FASTA

>TPDB91826|Antibacterial;Anticancer;Antifungal;Toxicity|length=16
LGGIVSAVKKIVDFLG-NH2

Formula C76H130N18O20

Absent Amino Acids RNCEQHMPTWY

Common Amino Acids GV

Mass 1615.98

PI 9.88

Basic Residues 2

Acidic Residues 1

Hydrophobic Residues 9

Net Charge +1

Boman Index 0.54

Hydrophobicity 1.281

Aliphatic Index 158.12

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 2 L: 2 K: 2 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 3

Length

Formula

C76H130N18O20

Mass

1615.98

9.88

Net Charge

Boman Index

0.54

Hydrophobicity

1.281

C_terminal_Modification

Amidation

Chirality

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial and Anticancer

Origin

Amphibian skin secretions

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50= 5 M

Detail Source Activity Anticancer

Activity Measurement 5

Target

Cancer Type Leukemia Cancer

Cell Line Leukemia tumor cellline

Tissue Affected Blood

Assay & Model

Assay Sulforhodamine B assay

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2003

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50= 5 M

Detail Source Activity Anticancer

Activity Measurement 5

Target

Cancer Type Lung Cancer

Cell Line Lung tumor cellline

Tissue Affected Lung

Assay & Model

Assay Sulforhodamine B assay

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2003

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50= >10 µM

Detail Source Activity Anticancer

Activity Measurement >10 µM

Target

Cancer Type Colon Cancer

Cell Line Colon tumor cellline

Tissue Affected Colon

Assay & Model

Assay Sulforhodamine B assay

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2003

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50= 5 M

Detail Source Activity Anticancer

Activity Measurement 5

Target

Cancer Type Brain Tumor

Cell Line Brain tumor cellline

Tissue Affected Brain

Assay & Model

Assay Sulforhodamine B assay

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2003

Evidence 5 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50= 5 M

Detail Source Activity Anticancer

Activity Measurement 5

Target

Cancer Type Skin Cancer

Cell Line Skin tumor cellline

Tissue Affected Skin

Assay & Model

Assay Sulforhodamine B assay

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2003

Evidence 6 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50= 5 M

Detail Source Activity Anticancer

Activity Measurement 5

Target

Cancer Type Ovarian Cancer

Cell Line Ovary tumor cellline

Tissue Affected Ovary

Assay & Model

Assay Sulforhodamine B assay

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2003

Evidence 7 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50= >10 µM

Detail Source Activity Anticancer

Activity Measurement >10 µM

Target

Cancer Type Liver Cancer

Cell Line Liver tumor celline

Tissue Affected Liver

Assay & Model

Assay Sulforhodamine B assay

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2003

Evidence 8 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50= >10 µM

Detail Source Activity Anticancer

Activity Measurement >10 µM

Target

Cancer Type Prostate Cancer

Cell Line Prostate tumor cellline

Tissue Affected Prostate

Assay & Model

Assay Sulforhodamine B assay

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2003

Evidence 9 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50= >10 µM

Detail Source Activity Anticancer

Activity Measurement >10 µM

Target

Cancer Type Breast Cancer

Cell Line Breast tumor cellline

Tissue Affected Breast

Assay & Model

Assay Sulforhodamine B assay

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2003