TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB91809

Peptide_Name

A4K14 - Citropin 1.1

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab

Sequence_Type

standard

Has_Modification No

Description A 16-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation N-terminal: Acetylation

Sequence

Ac-GLFAVIKKVASVIKGL-NH2

FASTA

>TPDB91809|Antibacterial;Anticancer;Toxicity|length=16
Ac-GLFAVIKKVASVIKGL-NH2

Formula C79H139N19O18

Absent Amino Acids RNDCEQHMPTWY

Common Amino Acids KV

Mass 1643.09

PI 10.84

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 10

Net Charge +3

Boman Index 0.12

Hydrophobicity 1.394

Aliphatic Index 164.37

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

2

A

0

R

0

N

0

D

0

C

0

E

0

Q

2

G

0

H

2

I

2

L

3

K

0

M

1

F

0

P

1

S

0

T

0

W

0

Y

3

V

Amino Acid Distribution

A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 2 K: 3 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 3

Length

16

Formula

C79H139N19O18

Mass

1643.09

PI

10.84

Net Charge

+3

Boman Index

0.12

Hydrophobicity

1.394

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Acetylation

Nature

Antimicrobial and Anticancer

Origin

Synthetic

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 29.05 µM

Detail Source Activity Anticancer

Activity Measurement 29.05 µM

Target

Cancer Type Prostate Cancer

Cell Line C4-2B

Tissue Affected Prostate

Assay & Model

Assay CCK-8 assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2020

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 14.97 µM

Detail Source Activity Anticancer

Activity Measurement 14.97 µM

Target

Cancer Type Lung Cancer

Cell Line A-549

Tissue Affected Lung

Assay & Model

Assay CCK-8 assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2020

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 14.8 µM

Detail Source Activity Anticancer

Activity Measurement 14.8 µM

Target

Cancer Type Brain Tumor

Cell Line U-87

Tissue Affected Brain

Assay & Model

Assay CCK-8 assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2020

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 14.16 µM

Detail Source Activity Anticancer

Activity Measurement 14.16 µM

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay CCK-8 assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2020