TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB91801

Peptide_Name

Lactoferricin B

Activity

Antibacterial Anticancer Antifungal Antiviral Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP pep-lab Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept CAFPdb AI4AVP

Sequence_Type

standard

Has_Modification No

Description A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

FKCRRWQWRMKKLGA-NH2

FASTA

>TPDB91801|Antibacterial;Anticancer;Antifungal;Antiviral;Toxicity|length=15
FKCRRWQWRMKKLGA-NH2

Formula C91H144N30O17S2

Absent Amino Acids NDEHIPSTYV

Common Amino Acids RK

Mass 1994.46

PI 12.14

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +6

Boman Index -0.04

Hydrophobicity -1.207

Aliphatic Index 32.67

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 11000

Absorbance 280nm 551.53

Polar Residues 2

number

1

A

3

R

0

N

0

D

1

C

0

E

1

Q

1

G

0

H

0

I

1

L

3

K

1

M

1

F

0

P

0

S

0

T

2

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 3 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 1 K: 3 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0

Length

15

Formula

C91H144N30O17S2

Mass

1994.46

PI

12.14

Net Charge

+6

Boman Index

-0.04

Hydrophobicity

-1.207

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antibacterial Antimicrobial

Origin

Temporins family

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=15.5 µM

Detail Source Activity Anticancer

Activity Measurement 15.5 µM

Target

Cancer Type Brain Tumor

Cell Line Kelly

Tissue Affected Brain

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2008

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=29 µM

Detail Source Activity Anticancer

Activity Measurement 29 µM

Target

Cancer Type Brain Tumor

Cell Line IMR-32

Tissue Affected Brain

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2008

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=37 µM

Detail Source Activity Anticancer

Activity Measurement 37 µM

Target

Cancer Type Brain Tumor

Cell Line SK-N-DZ

Tissue Affected Brain

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2008

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=45 µM

Detail Source Activity Anticancer

Activity Measurement 45 µM

Target

Cancer Type Brain Tumor

Cell Line SHEP-12

Tissue Affected Brain

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2008

Evidence 5 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=60 µM

Detail Source Activity Anticancer

Activity Measurement 60 µM

Target

Cancer Type Brain Tumor

Cell Line SH-SY-5Y2

Tissue Affected Brain

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2008