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Peptide record

TPDB91800

CM15 Antibacterial Anticancer Antifungal Antiparasitic Cell-penetrating Peptides Hemolysis Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB91800
CM15
Antibacterial Anticancer Antifungal Antiparasitic Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept CAFPdb dbAMP 3.0 CellPPD-MOD CPPsite3.0 APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with 5(6)-Carboxyfluorescein (CF)
Sequence
KWKLFKKIGAVLKVL-NH2
Physicochemical Analysis
C89H151N21O16
RNDCEQHMPSTY
K
1771.31
11.12
5
0
9
+5
-0.04
0.540
149.33
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
310.50
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
3
L
5
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 3 K: 5 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
15
C89H151N21O16
1771.31
11.12
+5
-0.04
0.540
Amidation
L
Cationic and amphiphilic
Linear
Conjugated with 5(6)-Carboxyfluorescein (CF)
N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Monomac-6, Ebc-1 And Calu-1 Cells Mycobacterium Tuberculosis H37Rv

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic and amphiphilic
Synthetic
CF dye and Isoniazid (INH) at N terminus
Lysosomes
In vitro
CCCCGGGTTTTTTTC
Additional Detail Fields 1 fields
CCCCGGGTTTTTTTC