TPDB

3D PDB MODEL

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TPDB ID TPDB91790

Peptide_Name

FR11P

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia CancerPPD 2.0 Antifungipept CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

FRRFFKWFRRPFKFF-NH2

FASTA

>TPDB91790|Antibacterial;Anticancer;Antifungal;Toxicity|length=15
FRRFFKWFRRPFKFF-NH2

Formula C115H154N30O16

Absent Amino Acids ANDCEQGHILMSTYV

Common Amino Acids F

Mass 2212.68

PI 12.88

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +6

Boman Index -4.09

Hydrophobicity -0.580

Aliphatic Index 0.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 248.57

Polar Residues 0

number

0

A

4

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

2

K

0

M

7

F

1

P

0

S

0

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 7 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

15

Formula

C115H154N30O16

Mass

2212.68

PI

12.88

Net Charge

+6

Boman Index

-4.09

Hydrophobicity

-0.580

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial and Anticancer

Origin

Analogue of FR-15

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 7 µM

Detail Source Activity Anticancer

Activity Measurement 7 µM

Target

Cancer Type Breast Cancer

Cell Line MDA-MB-231

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2017

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 11 µM

Detail Source Activity Anticancer

Activity Measurement 11 µM

Target

Cancer Type Cervical Cancer

Cell Line HeLa

Tissue Affected Cervix

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2017

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 12.9 µM

Detail Source Activity Anticancer

Activity Measurement 12.9 µM

Target

Cancer Type Colon Cancer

Cell Line DLD-1

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2017

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 4.8 µM

Detail Source Activity Anticancer

Activity Measurement 4.8 µM

Target

Cancer Type Liver Cancer

Cell Line HepG-2

Tissue Affected Liver

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2017