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Peptide record

TPDB91785

B1 Antibacterial Anticancer Antifungal Cell-penetrating Peptides Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB91785
B1
Antibacterial Anticancer Antifungal Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CancerPPD 2.0 Antifungipept CAFPdb dbAMP CellPPD-MOD CPPsite3.0
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
VKRFKKFFRKLKKSV-NH2
Physicochemical Analysis
C94H159N27O17
ANDCEQGHIMPTWY
K
1939.47
12.46
8
0
6
+8
3.88
-0.840
64.67
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
6
K
0
M
3
F
0
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 6 M: 0 F: 3 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
15
C94H159N27O17
1939.47
12.46
+8
3.88
-0.840
Amidation
L
Amphipathic
Linear
Linear
Free
Antimicrobial and Anticancer
Cathelicidin-BF15
N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)O N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O.N
Evidence Records 6 records
Evidence 1 Activity

Activity

IC50
IC50 = 21.9 µM
Anticancer
21.9 µM

Target

Breast Cancer
MCF-7
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 26.9 µM
Anticancer
26.9 µM

Target

Leukemia cancer
K-562
Blood

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015
Evidence 3 Activity

Activity

IC50
IC50 = 24.1 µM
Anticancer
24.1 µM

Target

Breast Cancer
MCF-7/ADM
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015
Evidence 4 Activity

Activity

IC50
IC50 = 31.6 µM
Anticancer
31.6 µM

Target

Leukemia cancer
K-562/ADM
Blood

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015
Evidence 5 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Fluorophore (FITC)
In vitro
CHHHHHHHHHHTTCC
Evidence 6 Activity

Activity

Cell-penetrating Peptides

Target

Cancer Cells (MCF-7, HeLa, Ht-29, A2780, A2780/Ptx) And Normal Cells (Ncm460, Hek-293).

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
5-carboxyfluorescein (5-FAM)
In vitro
CCCCGGGGGTCCCCCSSSSCCCSSCSSSCC
Additional Detail Fields 1 fields
CHHHHHHHHHHTTCC CCCCGGGGGTCCCCCSSSSCCCSSCSSSCC