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Peptide record

TPDB91779

Short α-helical peptides Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB91779
Short α-helical peptides
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF dbAMP dbAMP 3.0 HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
GIIKKIIKKIIKKI-NH2
Physicochemical Analysis
C80H154N20O15
ARNDCEQHLMFPSTWYV
I
1636.23
11.21
6
0
7
+6
3.78
0.550
195.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
7
I
0
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 7 L: 0 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C80H154N20O15
1636.23
11.21
+6
3.78
0.550
Amidation
L
Linear
Free
Antimicrobial
Alpha-helical proteins
Evidence Records 2 records
Evidence 1 Activity

Activity

95% Cytotoxicity at 4 µM Approx
Anticancer

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

MTT/MTS assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2014

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.
Evidence 2 Activity

Activity

90% Cytotoxicity at 5 µM Approx
Anticancer

Target

Leukemia Cancer
HL-60
Blood

Assay & Model

MTT/MTS assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2014