TPDB

3D PDB MODEL

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TPDB ID TPDB91767

Peptide_Name

DAP1

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia CancerPPD 2.0

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and CancerPPD 2.0, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

LWKRWVGVWRKWL-NH2

FASTA

>TPDB91767|Antibacterial;Anticancer;Toxicity|length=13
LWKRWVGVWRKWL-NH2

Formula C92H133N25O14

Absent Amino Acids ANDCEQHIMFPSTY

Common Amino Acids W

Mass 1813.23

PI 12.42

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +4

Boman Index -4.77

Hydrophobicity -0.369

Aliphatic Index 104.62

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 22000

Absorbance 280nm 1213.31

Polar Residues 0

number

0

A

2

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

2

L

2

K

0

M

0

F

0

P

0

S

0

T

4

W

0

Y

2

V

Amino Acid Distribution

A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 2

Length

13

Formula

C92H133N25O14

Mass

1813.23

PI

12.42

Net Charge

+4

Boman Index

-4.77

Hydrophobicity

-0.369

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial

Origin

Synthetic

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 11.9 µM

Detail Source Activity Anticancer

Activity Measurement 11.9 µM

Target

Cancer Type Lung Cancer

Cell Line A-549

Tissue Affected Lung

Assay & Model

Assay MTT assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2023

Patents US11571454 B2

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 8.6 µM

Detail Source Activity Anticancer

Activity Measurement 8.6 µM

Target

Cancer Type Ovarian Cancer

Cell Line OVCAR-3

Tissue Affected Ovary

Assay & Model

Assay MTT assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2023

Patents US11571454 B2

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 14.0 µM

Detail Source Activity Anticancer

Activity Measurement 14.0 µM

Target

Cancer Type Ovarian Cancer

Cell Line NCI/ADR-RES

Tissue Affected Lung

Assay & Model

Assay MTT assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2023

Patents US11571454 B2

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 15.3 µM

Detail Source Activity Anticancer

Activity Measurement 15.3 µM

Target

Cancer Type Bladder Cancer

Cell Line T-24

Tissue Affected Bladder

Assay & Model

Assay MTT assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2023

Patents US11571454 B2