TPDB

3D PDB MODEL

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TPDB ID TPDB91729

Peptide_Name

TAT–P9–Cy3 TAT–SP9–Cy3

Activity

Antibacterial Anticancer Cell-penetrating Peptides Toxicity Tumor-homing Peptides

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides

Database_Source

AntiBP3 Peptipedia CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CellPPD, and other sources, with an available 3D structural model.

Modification

C-terminal: Conjugated with Cyanine3(Cy3)

Sequence

GRKKRRQRRRPPQ

FASTA

>TPDB91729|Antibacterial;Anticancer;Cell-penetrating Peptides;Toxicity;Tumor-homing Peptides|length=13
GRKKRRQRRRPPQ

Formula C70H131N35O16

Absent Amino Acids ANDCEHILMFSTWYV

Common Amino Acids R

Mass 1719.04

PI 13.10

Basic Residues 8

Acidic Residues 0

Hydrophobic Residues 0

Net Charge +8

Boman Index 8.91

Hydrophobicity -3.492

Aliphatic Index 0.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

0

A

6

R

0

N

0

D

0

C

0

E

2

Q

1

G

0

H

0

I

0

L

2

K

0

M

0

F

2

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

13

Formula

C70H131N35O16

Mass

1719.04

PI

13.10

Net Charge

+8

Boman Index

8.91

Hydrophobicity

-3.492

C_terminal_Modification

Conjugated with Cyanine3(Cy3)

Chirality

L

Linearity

Stapled

N_terminal_Modification

Free

SMILES

N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)O

Evidence 1 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Hae Cells

Assay & Model

In Vitro Model C57BL/6J mice

In Vivo Model C57BL/6J mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Natural residues Stapled L

Source of Peptide Chimeric

Cargo Type Stapled peptide SP9 and Cy3 dye

Subcellular Localization Cytoplasm

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCSSSTTCCCTTTTC

Evidence 2 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Hae Cells

Assay & Model

In Vitro Model C57BL/6J mice

In Vivo Model C57BL/6J mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Stapled L

Source of Peptide Chimeric

Cargo Type P9 peptide and Cy3 dye

Subcellular Localization Cytoplasm

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCCCCCCCCCCC

DSSP_Secondary_Structure

CCCSSSTTCCCTTTTC CCCCCCCCCCCCC