TPDB

3D PDB MODEL

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TPDB ID TPDB91698

Peptide_Name

Tritrp-Arg Tritrpticin

Activity

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

VRRFPWWWPFLRR-NH2

FASTA

>TPDB91698|Antibacterial;Anticancer;Antifungal;Antiparasitic;Hemolysis;Toxicity|length=13
VRRFPWWWPFLRR-NH2

Formula C96H132N28O14

Absent Amino Acids ANDCEQGHIKMSTY

Common Amino Acids R

Mass 1902.28

PI 12.88

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +4

Boman Index -4.16

Hydrophobicity -0.792

Aliphatic Index 52.31

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 16500

Absorbance 280nm 867.38

Polar Residues 0

number

0

A

4

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

0

K

0

M

2

F

2

P

0

S

0

T

3

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 2 P: 2 S: 0 T: 0 W: 3 Y: 0 V: 1

Length

13

Formula

C96H132N28O14

Mass

1902.28

PI

12.88

Net Charge

+4

Boman Index

-4.16

Hydrophobicity

-0.792

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial

Origin

Derivative of tritrpticin Synthetic

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 >200 µg/ml

Detail Source Activity Anticancer

Activity Measurement 200 µg/mL

Target

Cancer Type Lung Cancer

Cell Line A-549

Tissue Affected Lung

Assay & Model

Assay MTT/MTS assay

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2008

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 =142 µg/ml

Detail Source Activity Anticancer

Activity Measurement 142 µg/mL

Target

Cancer Type Breast Cancer

Cell Line MDA-MB-361

Tissue Affected Breast

Assay & Model

Assay MTT/MTS assay

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2008

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 9.4 µM

Detail Source Activity Anticancer

Activity Measurement 9.4 µM

Target

Cancer Type Blood Cancer

Cell Line Jurkat

Tissue Affected Blood

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2020