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Peptide record

TPDB91688

Demegen P-113 Antibacterial Anticancer Antifungal Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB91688
Demegen P-113
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept CAFPdb dbAMP
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
AKRHHGYKRKFH-NH2
Physicochemical Analysis
C71H109N27O14
NDCEQILMPSTWV
HK
1564.82
11.59
8
0
3
+5
5.24
-2.283
8.33
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
95.22
1
Residue Composition
number
1
A
2
R
0
N
0
D
0
C
0
E
0
Q
1
G
3
H
0
I
0
L
3
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 3 I: 0 L: 0 K: 3 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C71H109N27O14
1564.82
11.59
+5
5.24
-2.283
Amidation
L
Linear
Free
Antimicrobial
Amphibian skin peptide Canaida albicans
Evidence Records 2 records
Evidence 1 Activity

Activity

15% Cytotoxicity at 0.5 µg/ml
Anticancer

Target

Lymphoma Cancer
U-937
Blood

Assay & Model

MTT/MTS assay
6-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2006

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 =85-90 µg/ml
Anticancer
85-90 µg/mL

Target

Lymphoma Cancer
U-939
Blood

Assay & Model

MTT/MTS assay
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011