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Peptide record

TPDB91683

OmigaNAn MBI-226 Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB91683
OmigaNAn MBI-226
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab Antifungipept CAFPdb dbAMP
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
ILRWPWWPWRRK-NH2
Physicochemical Analysis
C90H126N26O13
ANDCEQGHMFSTYV
W
1780.16
12.71
4
0
6
+4
-3.95
-1.325
65.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
22000
1235.85
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
1
K
0
M
0
F
2
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 2 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
12
C90H126N26O13
1780.16
12.71
+4
-3.95
-1.325
Amidation
L
Linear
Free
Antimicrobial
Helical peptide with a predominance of one or more amino acids tryptophane-rich Bovine neutrophils
Evidence Records 2 records
Evidence 1 Activity

Activity

27% Cytotoxicity at 0.5 µg/ml
Anticancer

Target

Lymphoma Cancer
U-937
Blood

Assay & Model

MTT/MTS assay
6-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2003

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 =80-85 µg/ml
Anticancer
80-85 µg/mL

Target

Lymphoma Cancer
U-937
Blood

Assay & Model

MTT/MTS assay
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011