TPDB

3D PDB MODEL

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TPDB ID TPDB91669

Peptide_Name

HAL-2/1

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

GKWKSLLKHILK-NH2

FASTA

>TPDB91669|Antibacterial;Anticancer;Antifungal;Toxicity|length=12
GKWKSLLKHILK-NH2

Formula C70H119N19O14

Absent Amino Acids ARNDCEQMFPTYV

Common Amino Acids K

Mass 1450.83

PI 11.00

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +4

Boman Index 1.22

Hydrophobicity -0.417

Aliphatic Index 130.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 379.09

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

1

H

1

I

3

L

4

K

0

M

0

F

0

P

1

S

0

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 3 K: 4 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0

Length

12

Formula

C70H119N19O14

Mass

1450.83

PI

11.00

Net Charge

+4

Boman Index

1.22

Hydrophobicity

-0.417

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial and Antifungal

Origin

Halictines and their analogs

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 14±2 µM

Detail Source Activity Anticancer

Activity Measurement 14

Target

Cancer Type Cervical Cancer

Cell Line HeLa

Tissue Affected Cervix

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 > 100 µM

Detail Source Activity Anticancer

Activity Measurement 100 µM

Target

Cancer Type Colon Cancer

Cell Line SW

Tissue Affected Colon

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 > 40 µM

Detail Source Activity Anticancer

Activity Measurement 40 µM

Target

Cancer Type Leukemia Cancer

Cell Line CCRF-CEM

Tissue Affected Blood

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012