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Peptide record

TPDB91662

R12 Antibacterial Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB91662
R12
Antibacterial Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Cell-penetrating Peptides) peptide sequence curated from AntiBP3, Peptipedia, CellPPD, and other sources, with an available 3D structural model.
Chemical: Cy5-labelled NCG nanoparticles
Sequence
RRRRRRRRRRRR
Physicochemical Analysis
C72H146N48O13
ANDCEQGHILKMFPSTWYV
R
1892.27
13.44
12
0
0
+12
9.72
-4.500
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
12
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 12 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C72H146N48O13
1892.27
13.44
+12
9.72
-4.500
Free
Cy5-labelled NCG nanoparticles
L
Linear
Free
N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Wrl-68, MCF-7, Caco-2, HUVEC, E0771, And Hbl-100

Assay & Model

zebrafish larvae, C57BL/6 female mice (6–8 weeks old) and Sprague–Dawley (SD) rats
zebrafish larvae, C57BL/6 female mice (6–8 weeks old) and Sprague–Dawley (SD) rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Naringenin (NAR)
Endoplasmic Reticulum, Lysosomes and Less In Mitochondria
NCG was more easily internalized by WRL-68 cells, and exhibited dose and Time-dependent uptake.
Caveolae mediated endocytosis
In vitro and in vivo
CCC
Additional Detail Fields 1 fields
CCC