TPDB

3D PDB MODEL

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TPDB ID TPDB91653

Peptide_Name

HAL-1/5

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

GMWKKILGHLIR-NH2

FASTA

>TPDB91653|Antibacterial;Anticancer;Antifungal;Toxicity|length=12
GMWKKILGHLIR-NH2

Formula C68H114N20O13S1

Absent Amino Acids ANDCEQFPSTYV

Common Amino Acids GILK

Mass 1451.84

PI 11.64

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +3

Boman Index -0.05

Hydrophobicity 0.108

Aliphatic Index 130.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 378.83

Polar Residues 0

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

2

G

1

H

2

I

2

L

2

K

1

M

0

F

0

P

0

S

0

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 2 L: 2 K: 2 M: 1 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

12

Formula

C68H114N20O13S1

Mass

1451.84

PI

11.64

Net Charge

+3

Boman Index

-0.05

Hydrophobicity

0.108

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial and Antifungal

Origin

Halictines and their analogs

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 9±1 µM

Detail Source Activity Anticancer

Activity Measurement 9

Target

Cancer Type Cervical Cancer

Cell Line HeLa

Tissue Affected Cervix

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 44±5 µM

Detail Source Activity Anticancer

Activity Measurement 44

Target

Cancer Type Colon Cancer

Cell Line SW

Tissue Affected Colon

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 > 40 µM

Detail Source Activity Anticancer

Activity Measurement 40 µM

Target

Cancer Type Leukemia Cancer

Cell Line CCRF-CEM

Tissue Affected Blood

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012