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Peptide record

TPDB91628

TAT Antibacterial Anticancer Antifungal Blood-Brain Barrier Cell-penetrating Peptides Toxicity Tumor-homing Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB91628
TAT
Antibacterial Anticancer Antifungal Blood-Brain Barrier Cell-penetrating Peptides Toxicity Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CancerPPD 2.0 SATPdb dbACP CAFPdb B3Pred BBPpredict CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP TumorHoPe2.0
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Chemical: anhydride (DA) group modified micelles
Sequence
YGRKKRRQRRR
Physicochemical Analysis
C64H118N32O14
ANDCEHILMFPSTWV
R
1559.85
12.71
8
0
1
+8
6.49
-3.636
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
95.52
2
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
11
C64H118N32O14
1559.85
12.71
+8
6.49
-3.636
Free
anhydride (DA) group modified micelles
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

L929 , A549 And 4T1 Cells

Assay & Model

Female BALB/c mice and nude mice (20 ± 2 g)
Female BALB/c mice and nude mice (20 ± 2 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
mPEG-10-Hydroxycamptothecin (HCPT)
Nucleus
At pH 6.8 for 3 h, the blue fluorescence from mPEG-HCPT-loaded PECL/DA-Tat-M enhanced significantly, and the mean fluorescence intensity was 10 times higher than that of groups incubated at pH 7.4.
Endocytosis
In vitro and in vivo
CCCSCTTSCC
Additional Detail Fields 1 fields
CCCSCTTSCC