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Peptide record

TPDB91618

TAT Antibacterial Anticancer Antifungal Blood-Brain Barrier Cell-penetrating Peptides Toxicity Tumor-homing Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB91618
TAT
Antibacterial Anticancer Antifungal Blood-Brain Barrier Cell-penetrating Peptides Toxicity Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CancerPPD 2.0 SATPdb dbACP CAFPdb B3Pred BBPpredict CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP TumorHoPe2.0
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Chemical: PEGylated gold nanoparticles
Sequence
YGRKKRRQRRR
Physicochemical Analysis
C64H118N32O14
ANDCEHILMFPSTWV
R
1559.85
12.71
8
0
1
+8
6.49
-3.636
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
95.52
2
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
11
C64H118N32O14
1559.85
12.71
+8
6.49
-3.636
Free
PEGylated gold nanoparticles
L
Cationic
Linear
Free
N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231/MDA-MB-231-Br Cells , Cn34-Br Cells

Assay & Model

6−8 week old female athymic nude mice
6−8 week old female athymic nude mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Doxorubicin
Nucleus
TAT-Au-Dox treated cells had significantly greater mean fluorescence intensity as compared to free Dox alone for all tested concentrations (p < 0.05 for 50 nM p < 0.001 for 100, 200, and 500 nM)
In vitro and in vivo
CCSSSSCSTTTC
Additional Detail Fields 1 fields
CCSSSSCSTTTC