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Peptide record

TPDB91606

TAT Antibacterial Anticancer Antifungal Blood-Brain Barrier Cell-penetrating Peptides Toxicity Tumor-homing Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB91606
TAT
Antibacterial Anticancer Antifungal Blood-Brain Barrier Cell-penetrating Peptides Toxicity Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CancerPPD 2.0 SATPdb dbACP CAFPdb B3Pred BBPpredict CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP TumorHoPe2.0
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Chemical: FITC-labeled mannosylated-β-cyclodextrin (Man-CD) nanocomplex
Sequence
YGRKKRRQRRR
Physicochemical Analysis
C64H118N32O14
ANDCEHILMFPSTWV
R
1559.85
12.71
8
0
1
+8
6.49
-3.636
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
95.52
2
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
11
C64H118N32O14
1559.85
12.71
+8
6.49
-3.636
Free
FITC-labeled mannosylated-β-cyclodextrin (Man-CD) nanocomplex
L
Hydrophilic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Dc 2.4, RAW 264.7, B16F10 And Bmdcs Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophilic
Protein derived
Tyrosinase-related protein 2 (Trp2)
uptake of the mSWC (Man-CD/WT (mSWC)) nano complex was significantly higher than that of SWC (CD/WT (SWC)), which indicated that mannose targeting increases the uptake of nano complex. The increasing positive rate and MFI (Mean Fluorescence Intensity) of SWC and mSWC depended on the effect of TAT.
Energy dependent pathway
In vitro
CCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCC