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Peptide record

TPDB91564

GA-W4 Antibacterial Anticancer Antifungal Hemolysis Toxicity standard

11 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB91564

Peptide_Name

GA-W4

Activity

Antibacterial Anticancer Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF dbAMP HemoPI Hemolytic2 PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 11-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

FLWWLFKWAWK-NH2

FASTA

>TPDB91564|Antibacterial;Anticancer;Antifungal;Hemolysis;Toxicity|length=11
FLWWLFKWAWK-NH2

Formula C89H111N17O12

Absent Amino Acids RNDCEQGHIMPSTYV

Common Amino Acids W

Mass 1610.97

PI 10.60

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +2

Boman Index -8.97

Hydrophobicity 0.327

Aliphatic Index 80.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 22000

Absorbance 280nm 1365.64

Polar Residues 0

number

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 2 M: 0 F: 2 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0

Length

Formula

C89H111N17O12

Mass

1610.97

10.60

Net Charge

Boman Index

-8.97

Hydrophobicity

0.327

C_terminal_Modification

Amidation

Chirality

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial

Origin

Undecapeptide analogues derived from Brevinin-1EMa

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 =22.59 µM

Detail Source Activity Anticancer

Activity Measurement 22.59 µM

Target

Cancer Type Renal Cancer

Cell Line A-498

Tissue Affected Renal

Assay & Model

Assay MTT/MTS assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 =15.88 µM

Detail Source Activity Anticancer

Activity Measurement 15.88 µM

Target

Cancer Type Lung Cancer

Cell Line A-549

Tissue Affected Lung

Assay & Model

Assay MTT/MTS assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 =14.80 µM

Detail Source Activity Anticancer

Activity Measurement 14.80 µM

Target

Cancer Type Colon Cancer

Cell Line HCT-116

Tissue Affected Colon

Assay & Model

Assay MTT/MTS assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 =13.77 µM

Detail Source Activity Anticancer

Activity Measurement 13.77 µM

Target

Cancer Type Gastric Cancer

Cell Line MKN-45

Tissue Affected Stomach

Assay & Model

Assay MTT/MTS assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Evidence 5 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 =24.32 µM

Detail Source Activity Anticancer

Activity Measurement 24.32 µM

Target

Cancer Type Prostate Cancer

Cell Line PC-3

Tissue Affected Prostate

Assay & Model

Assay MTT/MTS assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Evidence 6 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 =13.16 µM

Detail Source Activity Anticancer

Activity Measurement 13.16 µM

Target

Cancer Type Skin Cancer

Cell Line SK-MEL-2

Tissue Affected Skin

Assay & Model

Assay MTT/MTS assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Evidence 7 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 =14.58 µM

Detail Source Activity Anticancer

Activity Measurement 14.58 µM

Target

Cancer Type Ovarian Cancer

Cell Line SK-OV-3

Tissue Affected Ovary

Assay & Model

Assay MTT/MTS assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012