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Peptide record

TPDB91538

Mut5DPT Antibacterial Cell-penetrating Peptides Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB91538
Mut5DPT
Antibacterial Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CPPsite3.0
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Cell-penetrating Peptides, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and CPPsite3.0, with an available 3D structural model.
C-terminal: Conjugated with FITC
Sequence
KKWKKWKKWKK
Physicochemical Analysis
C81H128N22O12
ARNDCEQGHILMFPSTYV
K
1602.05
11.36
8
0
3
+8
2.37
-3.082
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
16500
1029.93
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
8
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 8 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
11
C81H128N22O12
1602.05
11.36
+8
2.37
-3.082
Conjugated with FITC
L
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF7, Jurkat Cells, MDA-MB233

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FITC dye and PP2A/SET peptide
Cytoplasm
Rapid internalization and stronger than in the control Mut3DPT shuttle
In vitro
CCTTCHHHHHHHSCCC
Additional Detail Fields 1 fields
CCTTCHHHHHHHSCCC