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Peptide record

TPDB91534

GA-K4 Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB91534
GA-K4
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab dbAMP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
FLKWLFKWAKK-NH2
Physicochemical Analysis
C79H115N17O12
RNDCEQGHIMPSTYV
K
1494.89
11.00
4
0
7
+4
-3.29
-0.218
80.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
11000
735.84
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
4
K
0
M
2
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 4 M: 0 F: 2 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
11
C79H115N17O12
1494.89
11.00
+4
-3.29
-0.218
Amidation
L
Linear
Free
Antimicrobial
Undecapeptide analogues derived from Brevinin-1EMa
Evidence Records 7 records
Evidence 1 Activity

Activity

IC50
IC50 =21.48 µM
Anticancer
21.48 µM

Target

Renal Cancer
A-498
Renal

Assay & Model

MTT/MTS assay
72-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 =14.53 µM
Anticancer
14.53 µM

Target

Lung Cancer
A-549
Lung

Assay & Model

MTT/MTS assay
72-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012
Evidence 3 Activity

Activity

IC50
IC50 =14.80 µM
Anticancer
14.80 µM

Target

Colon Cancer
HCT-116
Colon

Assay & Model

MTT/MTS assay
72-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012
Evidence 4 Activity

Activity

IC50
IC50 =22.51 µM
Anticancer
22.51 µM

Target

Gastric Cancer
MKN-45
Stomach

Assay & Model

MTT/MTS assay
72-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012
Evidence 5 Activity

Activity

IC50
IC50 =29.10 µM
Anticancer
29.10 µM

Target

Prostate Cancer
PC-3
Prostate

Assay & Model

MTT/MTS assay
72-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012
Evidence 6 Activity

Activity

IC50
IC50 =22.25 µM
Anticancer
22.25 µM

Target

Skin Cancer
SK-MEL-2
Skin

Assay & Model

MTT/MTS assay
72-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012
Evidence 7 Activity

Activity

IC50
IC50 =12.55 µM
Anticancer
12.55 µM

Target

Ovarian Cancer
SK-OV-3
Ovary

Assay & Model

MTT/MTS assay
72-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012